Steroid-sensitive nephrotic syndrome and vascular endothelial growth factor gene polymorphisms

T, -141 A --> C and +405 G --> C. As VEGF has been postulated to play a role in the pathogenesis of childhood steroid-sensitive nephrotic syndrome (SSNS), this study tested the hypothesis that VEGF genotype may be associated with susceptibility to SSNS. We examined the genotype frequencies of these polymorphisms in a total of 116 children with SSNS and 150 control subjects, using polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). There were no statistically significant differences in any of the genotype frequencies between SSNS patients and controls. We conclude that VEGF -460, -141 and +405 genotypes are not associated with susceptibility to childhood SSNS. -->

ISSN:	0960-7420
DOI:	10.1046/j.1365-2370.2003.00360.x
Přístupová URL adresa:	https://explore.openaire.eu/search/publication?articleId=doi_________::7970b925b9cf6b84d8f959d98afcd5ee https://doi.org/10.1046/j.1365-2370.2003.00360.x
Rights:	CLOSED
Přírůstkové číslo:	edsair.doi...........7970b925b9cf6b84d8f959d98afcd5ee
Autor:	Peter W. Mathieson, Christine J. Watson, Nicholas J. A. Webb, S A Ralph, Arthur Clark, R C L Holt, Paul Brenchley
Rok vydání:	2003
Předmět:	medicine.medical_specialty Immunology Single-nucleotide polymorphism Biology Genotype frequency Vascular endothelial growth factor Vascular endothelial growth factor A chemistry.chemical_compound Endocrinology chemistry Polymorphism (computer science) Internal medicine Genotype Gene expression Genetics medicine Cancer research Allele frequency
Zdroj:	European Journal of Immunogenetics. 30:1-3
ISSN:	0960-7420
DOI:	10.1046/j.1365-2370.2003.00360.x
Popis:	Genetic polymorphisms have been recognized as important determinants of gene expression. Three common single nucleotide polymorphisms have been identified in the promoter and 5' untranslated region of the vascular endothelial growth factor (VEGF) gene: -460 C --> T, -141 A --> C and +405 G --> C. As VEGF has been postulated to play a role in the pathogenesis of childhood steroid-sensitive nephrotic syndrome (SSNS), this study tested the hypothesis that VEGF genotype may be associated with susceptibility to SSNS. We examined the genotype frequencies of these polymorphisms in a total of 116 children with SSNS and 150 control subjects, using polymerase chain reaction-restriction fragment length polymorphism analysis (PCR-RFLP). There were no statistically significant differences in any of the genotype frequencies between SSNS patients and controls. We conclude that VEGF -460, -141 and +405 genotypes are not associated with susceptibility to childhood SSNS.
Databáze:	OpenAIRE
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