Novel Dual Use of Formamide-POCl3 Mixture for the Efficient, One-Pot Synthesis of Condensed 2H-Pyrimidin-4-amine Libraries Under Microwave Irradiation

Autor:	Santosh S. Tompe, Pratip K. Chaskar, K. S. Jain, Muthu K. Kathiravan, Nikhilesh Arya, Jitender Bariwal
Rok vydání:	2012
Předmět:	Formamide chemistry.chemical_compound Pyrimidine chemistry Organic Chemistry One-pot synthesis Microwave irradiation food and beverages Organic chemistry Amine gas treating Combinatorial chemistry
Zdroj:	Synthetic Communications. 43:719-727
ISSN:	1532-2432 0039-7911
DOI:	10.1080/00397911.2011.607934
Popis:	The novel dual use of formamide-POCl3 mixture for the incorporation of a C-N fragment to form the pyrimidine nucleus and its subsequent chlorination in an efficient, one-pot synthesis of potentially bioactive condensed 2H-pyrimidin-4-amine libraries under microwave irradiation (MWI) is reported. The one-pot microwave-assisted synthetic protocol is high-yielding, ecofriendly, rapid, and novel as well as eliminates intermittent workups. The protocol can be adapted for the library synthesis of series of a condensed pyrimidines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7960c8d19ff0814013a0ee7971e996a9 https://doi.org/10.1080/00397911.2011.607934 Zobrazit plný text záznamu