Live, Attenuated Venezuelan Equine Encephalomyelitis Virus Vaccine

Autor:	Ralph D. Feigin, Robert W. Mckinney, Aristides C. Alevizatos
Rok vydání:	1967
Předmět:	Leukopenia Hemagglutination business.industry Antibody titer Viremia medicine.disease Serology Vaccination Infectious Diseases Immunization Virology Immunology medicine Parasitology medicine.symptom business Encephalitis
Zdroj:	The American Journal of Tropical Medicine and Hygiene. 16:762-768
ISSN:	1476-1645 0002-9637
Popis:	Summary Forty young men were inoculated with live, attenuated VEE virus vaccine, and as evidenced by a significant increase in hemagglutination-inhibiting antibody titers, all were infected. However, viremia was demonstrated in only 13. The level of viremia was low, varied with time, and occurred between 60 hours and 12 days after vaccination. All subjects were evaluated closely from clinical, laboratory, virologic, and serologic standpoints. Some degree of reaction was seen in 37.5% of these persons, 10% of them having a 3+ reaction, of a possible 4+. Viremia was demonstrated in 32.5%. Transient electrocardiographic abnormalities were noted in 47.5%, and 40% had transient leukopenia. Eight men followed with daily electroencephalographic tracings demonstrated no significant change subsequent to vaccination. There was no consistent positive or negative correlation between any of these responses or combination of responses.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::795fc54a4c57cf6629bf539c0145009b https://doi.org/10.4269/ajtmh.1967.16.762 Zobrazit plný text záznamu