The synthesis of 3-bromo-2,4,5-trifluorobenzoic acid and its conversion to 8-bromoquinolonecarboxylic acids

Autor:	Joseph P. Sanchez, John M. Domagala, Thomas E. Renau
Rok vydání:	1996
Předmět:	chemistry.chemical_compound Chemistry Organic Chemistry Organic chemistry chemistry.chemical_element Oxazoline Boron
Zdroj:	Journal of Heterocyclic Chemistry. 33:1407-1411
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570330466
Popis:	A series of 8-bromo-4-oxo-3-quinolinecarboxylic acids was prepared via the borate ester, 8. The key intermediate in the synthesis of the final products 10a-10d was 3-bromo-2,4,5-trifluorobenzoic acid (3), conveniently prepared in two steps from the known oxazoline, 1. The preparation of 10a-10d is a significant improvement of the literature procedure currently available for the synthesis of these compounds.
Databáze:	OpenAIRE
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