Serotype Distribution and Antimicrobial Resistance of Invasive and Noninvasive Streptococcus pneumoniae Isolates in Korea between 2014 and 2016
| Autor: | Joseph Jeong, Jayoung Kim, Young Ree Kim, Min Jung Kwon, Jaehyeon Lee, Kyu-Taeg Lee, Chul Park, Chulhun L. Chang, Sook Jin Jang, In Bum Suh, Hee Joo Lee, Jongyoun Yi, Soo Hyun Kim, Hee Won Moon, Ki Ho Hong, Jong-Wan Kim, Dongchul Park, Sae Am Song, Yong Hak Sohn, Chae Hoon Lee, Kwang Sook Woo, Sunjoo Kim, Si-Hyun Kim, Miae Lee, Hun Suk Suh, Sang-Hyun Hwang, Hye In Woo, Jae Woo Chung, Seonggyu Lee, Hae Kyung Lee, Hyun Soo Kim, Kyeong Seob Shin, Jong Hee Shin, Namhee Ryoo, Wonkeun Song, Kyoung Un Park, Mi-Kyung Lee, Jeong Hwan Shin, Dongeun Yong, Ji-Hyun Cho, Yu Kyung Kim, Seok Jeong |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Serotype Cefotaxime business.industry 030106 microbiology Biochemistry (medical) Clinical Biochemistry General Medicine medicine.disease_cause Pneumococcal polysaccharide vaccine Pneumococcal conjugate vaccine Microbiology Penicillin 03 medical and health sciences 0302 clinical medicine Antibiotic resistance Pneumococcal vaccine Streptococcus pneumoniae medicine 030212 general & internal medicine business medicine.drug |
| Zdroj: | Annals of Laboratory Medicine. 39:537-544 |
| ISSN: | 2234-3814 2234-3806 |
| DOI: | 10.3343/alm.2019.39.6.537 |
| Popis: | Background Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the serotype distribution and antimicrobial resistance of S. pneumoniae isolated between 2014 and 2016 in Korea. Methods We collected a total of 1,855 S. pneumoniae isolates from 44 hospitals between May 2014 and May 2016, and analyzed the serotypes by sequential multiplex PCR. We investigated the distribution of each serotype by patient age, source of the clinical specimen, and antimicrobial resistance pattern. Results The most common serotypes were 11A (10.1%), followed by 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), and 35B (6.2%). The major invasive serotypes were 3 (12.6%), 19A (7.8%), 34 (7.8%), 10A (6.8%), and 11A (6.8%). Serotypes 10A, 15B, 19A, and 12F were more common in patients ≤5 years old, while serotype 3 was more common in patients ≥65 years old compared with the other age groups. The coverage rates of pneumococcal conjugate vaccine (PCV)7, PCV10, PCV13, and pneumococcal polysaccharide vaccine 23 were 11.8%, 12.12%, 33.3%, and 53.6%, respectively. Of the 1,855 isolates, 857 (46.2%) were multi-drug resistant (MDR), with serotypes 11A and 19A predominant among the MDR strains. The resistance rates against penicillin, cefotaxime, and levofloxacin were 22.8%, 12.5%, and 9.4%, respectively. Conclusions There were significant changes in the major S. pneumoniae serotypes in the community. Non-PCV13 serotypes increased in patients ≤5 years old following the introduction of national immunization programs with the 10- and 13-polyvalent vaccines. |
| Databáze: | OpenAIRE |
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