The Cumulative Incidence and Risk Factors of Recurrent Venous Thromboembolism in the Elderly
| Autor: | Fahad A.S. Al-Eidan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism Population 030204 cardiovascular system & hematology Malignancy 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Pharmacology (medical) Cumulative incidence cardiovascular diseases 030212 general & internal medicine education Prospective cohort study education.field_of_study business.industry Proportional hazards model Incidence (epidemiology) Hazard ratio Public Health Environmental and Occupational Health Hematology General Medicine equipment and supplies medicine.disease Metformin Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Vascular Health and Risk Management. 16:437-443 |
| ISSN: | 1178-2048 |
| DOI: | 10.2147/vhrm.s264814 |
| Popis: | Background Incidence and outcomes of recurrent venous thromboembolism (VTE) in the elderly are still not fully elucidated. The purpose of this study was to determine the incidence and identify the risk factors of VTE recurrence in this population. Methods A prospective cohort study of a one-year follow-up of 277 patients aged ≥65 years with primary VTE was performed at King Abdulaziz Medical City, a tertiary care teaching hospital in Riyadh, Saudi Arabia. Demographic data, risk factors, and the consequences of VTE (recurrence, bleeding, and mortality) were recorded. Results Of the 277 VTE patients, 39 (14%) were diagnosed with recurrent VTE over a median follow-up period of 12 months. The cumulative incidence of recurrent VTE was 12.75 per hundred patient-year (95% CI, 8.24-17.36). In multivariate Cox regression, malignancy (hazard ratio [HR], 2.87, 95% CI, 1.32-6.24, p=0.008) and surgery (HR 2.78, 95% CI, 1.36-5.67, p=0.005) were identified as independent risk factors for recurrent VTE. Metformin had a significant independent protection effect (HR, 0.16, 95% CI, 0.08-0.33, p |
| Databáze: | OpenAIRE |
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