Cancer mortality from soft-tissue sarcoma and malignant lymphomas in an international cohort of workers exposed to chlorophenoxy herbicides and chlorophenols
| Autor: | Manolis Kogevinas, Margareta Littorin, B.H. Bueno de Mesquita, John D. Mathews, Elsebeth Lynge, John Osman, Regina Winkelmann, David Coggon, Lois M. Green, Neil Pearce, Pier Alberto Bertazzi, Timo Kauppinen, R. Saracci, Manfred Neuberger |
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| Rok vydání: | 1992 |
| Předmět: |
Cancer mortality
Oncology medicine.medical_specialty Environmental Engineering Health Toxicology and Mutagenesis Soft tissue sarcoma Public Health Environmental and Occupational Health Absolute risk reduction General Medicine General Chemistry medicine.disease Pollution Malignant lymphoma Internal medicine Epidemiology Cohort medicine Environmental Chemistry Occupational exposure Sarcoma |
| Zdroj: | Chemosphere. 25:1071-1076 |
| ISSN: | 0045-6535 |
| Popis: | Mortality from soft-tissue sarcoma and malignant lymphomas was examined in an international register including 18,910 production workers or sprayers from 10 countries. Exposure to chlorophenoxy herbicides and chlorophenols was evaluated from job histories in conjunction with information collected through company questionnaires and other exposure related documents. No excess was observed for malignant lymphomas. A two-fold excess risk, based on four observed deaths, was observed overall for soft-tissue sarcoma; the risk was concentrated as an about six-fold statistically significant excess, occurring 10 to 19 years from first exposure in the cohort as a whole, and was highest among sprayers. In the present set of data the excess does not appear specifically associated with those chlorophenoxy herbicides probably contaminated by TCDD. |
| Databáze: | OpenAIRE |
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