Novel nucleophilic substitution of alkyl bromo-2(1H)-pyridones

Autor:	Arsenio A. Pessolano, T. Y. Shen, J. Carty, Howard Jones, Patricia M. Graham, C. P. Dorn, B. E. Witzel, Robert L Clark
Rok vydání:	1985
Předmět:	chemistry.chemical_classification Substitution reaction Stereochemistry Organic Chemistry Ring (chemistry) Medicinal chemistry chemistry.chemical_compound chemistry Nucleophile Nucleophilic substitution Side chain Lactam Piperidine Alkyl
Zdroj:	Journal of Heterocyclic Chemistry. 22:265-272
ISSN:	1943-5193 0022-152X
DOI:	10.1002/jhet.5570220205
Popis:	Nucleophilic substitution of certain alkyl bromo-2(1H)-pyridones gave some unexpected products where the alkyl group is substituted and the ring bromine is replaced by hydrogen. The expected ring substituted product is also formed, but only as the minor product in most cases. Many reactions are cited with various nucleophiles, and a plausible mechanism is also presented.
Databáze:	OpenAIRE
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