Functional Status of Hypothalamic-pituitary-thyroid axis and Prolactin level in Patients with First-episode of Bipolar Disorder in Mania State
| Autor: | Huaihui Zhang, Fang Wang, Yuncheng Zhu, Jun Wang, Dongmei Zhao |
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| Rok vydání: | 2020 |
| Předmět: |
First episode
medicine.medical_specialty business.industry Prolactin level medicine.disease Hypothalamic–pituitary–thyroid axis Endocrinology Internal medicine mental disorders medicine Functional status In patient Bipolar disorder medicine.symptom business Mania hormones hormone substitutes and hormone antagonists |
| Popis: | Background Bipolar disorder (BD)-mania symptoms are stimulated by disease of the thyroid. Methods This study included 70 patients diagnosed with first-episode BD-mania and 70 healthy controls (HC) matched for age and sex. We aimed to determine upstream thyroid hormone interactions on the anterior pituitary, and find differences between thyroid-stimulating-hormone (TSH) and Prolactin (PRL) in the patients with first-episode of BD-mania. There were significant changes in triiodothyronine (TT3), total thyroxin (TT4), and free thyroxine (FT4) concentrations between the BD-mania and HC groups (p p’s p < 0.01) while the female BD-mania group showed lower TT3 and TT4 compared to the HC females (p’s < 0.01). In the female BD-mania group, correlation analysis established an inverse relationship between PRL and TSH (r2 = 0.25, F = 11.11, p |
| Databáze: | OpenAIRE |
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