A Four Parameter Microfluidic Tandem SAW-IS Bio-Sensor
| Autor: | Aldo Jesorka, Kiryl Kustanovich, Ventsislav Yantchev |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Tandem Test fixture business.industry 010401 analytical chemistry Microfluidics Reflector (antenna) 02 engineering and technology Quartz crystal microbalance 021001 nanoscience & nanotechnology 01 natural sciences 0104 chemical sciences law.invention Capacitor law Proof of concept Optoelectronics 0210 nano-technology business Biosensor |
| Zdroj: | 2019 IEEE International Ultrasonics Symposium (IUS). |
| DOI: | 10.1109/ultsym.2019.8926159 |
| Popis: | Surface Acoustic Resonance (SAR) biosensing has recently been proposed as a highly compact and robust alternative to the conventional SAW delay-line based biosensing. The device can also be presented as a one-port high frequency alternative to the QCM, employing SAW resonance. It enables simple one-port measurements at low powers, while offering robust integration with microfluidics and implementation in integrated sensor arrays. Here we discuss the SAR approach as a key enabling and demonstrate its integration with the impedance spectroscopy (IS) concept in a single microfluidic device. The IS is integrated within a SAW reflector formed as interdigitated electrode (IDE) capacitor. A test fixture with SAW and IS ports is designed and fabricated. Four sensitive parameters are deduced from the tandem sensor readout and employed in a proof of principle study of liposome layers and their interaction with Ca2+ ions. |
| Databáze: | OpenAIRE |
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