Síndrome de Guillain-Barré asociado a infección por COVID-19: revisión de casos publicados
| Autor: | J. V. Martinez, P Bonardo, L León-Cejas, A Miquelini, Ricardo Reisin, F Maximiliano-González, M V Gutiérrez, M E Conti, P Zuberbühler, J Halfon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Weakness Guillain-Barre syndrome business.industry Muscle weakness Retrospective cohort study General Medicine medicine.disease Dysgeusia 03 medical and health sciences 0302 clinical medicine Respiratory failure Hyposmia Internal medicine medicine Cranial nerve disease Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Revista de Neurología. 72:203 |
| ISSN: | 0210-0010 |
| DOI: | 10.33588/rn.7206.2020487 |
| Popis: | Introduction The coronavirus disease 2019 (COVID-19) pandemic is a major worldwide health disorder. There is an increasing number of neurological complications recognized with COVID-19 including patients with GBS and its variants. Development A review of the clinical cases of GBS associated to COVID-19 infection published in the last months has been developed. We included 48 patients (31 men, mean age 56.4 years). The most common COVID-19 symptoms were cough (60.4%) and fever (56.3%). Mean time from COVID-19 symptoms to neurologic manifestations was 12.1 days, but in nine patients (18.8%) developed GBS within seven days. Eleven patients (22.9%) presented cranial nerve involvement in the absence of muscle weakness; 36 presented the classic sensory motor variant (75%) and one had a pure motor variant (2.1%). The electrodiagnostic pattern was considered demyelinating in 82.4% of the generalized variants. The presence of hyposmia/dysgeusia was associated with a latency shorter than seven days to GBS onset of symptoms (30% vs 15.6%), and cranial nerve involvement in the absence of weakness (30.8% vs 17.1%). Most patients (87.5%) were treated with intravenous immunoglobulin. Neurological outcome was favorable in 64.6%; 29.2% had respiratory failure and 4.2% died shortly after being admitted. Conclusions GBS in patients with SARS-CoV-2 infection resembles clinically and electrophysiology the classical forms. Further studies are necessary to understand whether GBS frequency is actually increased due to SARS-CoV-2 infection and explore pathogenic mechanisms. |
| Databáze: | OpenAIRE |
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