Corticosteroid Binding Globulin
| Autor: | Gustav F. Jirikowski, Elena V. Sivukhina, Andrea Rodewald, Jack D. Caldwell |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
biology Chemistry Adrenal cortex medicine.medical_treatment Steroid Endocrinology medicine.anatomical_structure Transcortin Internal medicine Neutrophil elastase medicine biology.protein Receptor hormones hormone substitutes and hormone antagonists Glucocorticoid Intracellular Hormone medicine.drug |
| Popis: | Corticosteroid binding globulin is a well characterized glycoprotein capable of binding adrenal steroid hormones. Plasma corticosteroid binding globulin originates mostly from liver and regulates systemic bioavailability of glucocorticoids and mineralocorticoids. At the membrane of glucocorticoid target cells the affinity of corticosteroid binding globulin for adrenal steroids is lowered by neutrophil elastase, which may control entry of glucocorticoids into the target cell. Glucocorticoids are known to have anti-inflammatory actions on numerous cellular targets by affecting cytokine release via fast, non-genomic mechanisms. Corticosteroid binding globulin is expressed in various tissues including brain, adrenal cortex, and gonads. Intracellular corticosteroid binding globulin may be of importance for transporting steroids through the cell membrane to cytoplasmic steroid receptors for translocation into the nucleus. Cytoplasmic corticosteroid binding globulin may also be important for transport and liberation of glucocorticoids synthetized by mitochondria. |
| Databáze: | OpenAIRE |
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