| Autor: |
Satoshi Kitamura, Akira Miyamae, Shigetaka Koda, Tsutomu Yasuda, Yukiyoshi Morimoto |
| Rok vydání: |
1990 |
| Předmět: |
|
| Zdroj: |
International Journal of Pharmaceutics. 59:217-224 |
| ISSN: |
0378-5173 |
| DOI: |
10.1016/0378-5173(90)90112-h |
| Popis: |
Partially dehydrated cefixime trihydrate was found to be unstable due to a highly disordered crystal structure caused by loss of its water of crystallization. It was also confirmed that cefixime trihydrate stored at a relative humidity below its critical value was less stable than the trihydrate stored under moist conditions. On the other hand, completely dehydrated cefixime trihydrate was relatively stable since it underwent transformation to a new anhydrous crystal form which did not contain water capable of participating in the hydrolytic reaction. It was suggested that the degradation mechanism under conditions of dryness differed from that under conditions of humidity, since not only the appearance but also the particular species of degradation products were completely different under the two sets of conditions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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