CagA+Helicobacter pyloriinfection and gastric cancer risk in the EPIC-EURGAST study

Autor: Jakob Linseisen, Antonia Trichoupoulou, Marie-Christine Boutron-Ruault, Kay-Tee Khaw, Kim Overvad, Heiner Boeing, Françoise Clavel-Chapelon, Salvatore Panico, Carlos A. González, José Ramón Quirós, Mattijs E. Numans, Elio Riboli, Cornelia Weikert, H. Bas Bueno de Mesquita, Petra H.M. Peeters, Giovanna Masala, Guillem Pera, Henrik Simán, Daniela Basso, Fátima Carneiro, Marco Ceroti, Anja Olsen, Gabriella Nesi, María José Sánchez, Paolo Vineis, Mazda Jenab, Reimar W. Thomsen, Calogero Saieva, Carmen Navarro, Göran Hallmans, Vittorio Krogh, Naomi E. Allen, Aurelio Barricarte, Pietro Ferrari, Duccio Berti, Göran Berglund, Sheila Bingham, Timothy J. Key, Rosario Tumino, Domenico Palli, Mario Plebani, Rudolf Kaaks, Nerea Larrañaga, Frederike L. Büchner, Gabriele Nagel, Giuseppe Del Giudice, Athina Arvaniti, Olof Nyrén, Anne Tjønneland, Dimitrios Trichopoulos
Rok vydání: 2006
Předmět:
Zdroj: International Journal of Cancer. 120:859-867
ISSN: 0020-7136
Popis: Helicobacter pylori (H. pylori), atrophic gastritis, dietary and life-style factors have been associated with gastric cancer (GC). These factors have been evaluated in a large case-control study nested in the European Prospective Investigation into Cancer and Nutrition carried out in 9 countries, including the Mediterranean area. Participants, enrolled in 1992-1998, provided life-style and dietary information and a blood sample (360,000; mean follow-up: 6.1 years). For 233 GC cases diagnosed after enrolment and their 910 controls individually-matched by center, gender, age and blood donation date H. pylori antibodies (antilysate and antiCagA) and plasma Pepsinogen A (PGA) were measured by ELISA methods. Severe chronic atrophic gastritis (SCAG) was defined as PGA circulating levels
Databáze: OpenAIRE