| Autor: |
Bartas, Martin, Slychko, Kristyna, Br��zda, V��clav, ��erve��, Ji����, Beaudoin, Christopher, Blundell, Tom, Pe��inka, Petr |
| Rok vydání: |
2022 |
| DOI: |
10.17863/cam.80167 |
| Popis: |
Z-DNA and Z-RNA are functionally important left-handed structures of nucleic acids, which play a significant role in several molecular and biological processes including DNA replication, gene expression regulation and viral nucleic acid sensing. Most proteins that have been proven to interact with Z-DNA/Z-RNA contain the so-called Z�� domain, which is structurally well conserved. To date, only eight proteins with Z�� domain have been described within a few organisms (including human, mouse, Danio rerio, Trypanosoma brucei and some viruses). Therefore, this paper aimed to search for new Z-DNA/Z-RNA binding proteins in the complete PDB structures database and from the AlphaFold2 protein models. A structure-based similarity search found 14 proteins with highly similar Z�� domain structure in experimentally-defined proteins and 185 proteins with a putative Z�� domain using the AlphaFold2 models. Structure-based alignment and molecular docking confirmed high functional conservation of amino acids involved in Z-DNA/Z-RNA, suggesting that Z-DNA/Z-RNA recognition may play an important role in a variety of cellular processes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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