| Autor: |
Bolajoko A. Akinpelu, Ogundana Timileyin, Adetoun Elizabeth Morakinyo, Ayodeji Adepoju, Oluboade Oluokun Oyedapo, Temitope A. Oyedepo, Ifeoluwani Akinlusi |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Cardiovascular disorder is one of the causes of death globally. Quite a number of medicinal plants have been demonstrated to possess and exhibit beneficial effects on cardiovascular system throuhg their antioxidant properties. The study investigated thein vivoantioxidant properties of aqueousC. albidiumpulp extract on isoproterenol-induced cardiotoxicity in albino rats. Cardiotoxicity was induced in rats by subcutaneous injection of ISO (85 mg/kg bwt) into adult albino rats and treated with the extract (100 and 200 mg/kg bwt). The levels of nitrite, lipid peroxidation, reduced glutathione total protein and activities of glutathione peroxidase, catalase and superoxide dismutase were evaluated using standard methods. The concentration of total protein was also determined. Administration of ISO (85 mg/kg body weight) caused significant (p< 0.05) reduction in the antioxidant status of animals. The enzymatic and non-enzymatic antioxidants perturbed by the administration of ISO were restored in theC. albidiumtreated rats. The study concludes that the aqueous extract ofC. albidumpulp protected against Isoproterenol-induced cardiotoxicity in adult male Albino rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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