| Popis: |
The swelling and water sorption properties of an experimental, cross-linked polyalkylammonium polymer and three other super disintegrants, i.e. crospovidone, sodium starch glycolate, and croscarmellose sodium, were evaluated via water vapor uptake, water uptake, and dry/wet particle size measurements. Direct compression formulations containing either aspirin or hydrochlothiazide as a model drug, dibasic calcium phosphate as a bulking agent, and the aforementioned disintegrants at two levels (0.25 and 1%) were tableted on a single station Manesty F-3 press. The disintegration and dissolution tests demonstrated that the crosslinked polyalkylammonium polymer possesses effective disintegrant properties, e.g. consistently fast disintegration, rapid dissolution, and is effective at low concentrations. |
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