A synthesis of oxytocin
| Autor: | J. S. Bontekoe, A. C. Koch, H. C. Beyerman |
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| Rok vydání: | 2010 |
| Předmět: | |
| Zdroj: | Recueil des Travaux Chimiques des Pays-Bas. 78:935-946 |
| ISSN: | 0165-0513 |
| DOI: | 10.1002/recl.19590781202 |
| Popis: | The synthesis is described of the “protected” linear nonapeptide: N-benzyloxycarbonyl-S-benzyl-L-cysteinyl-L-tyrosyl-L-isoleucyl-L-glutaminyl-L-asparaginyl-S-benzyl-L-cysteinyl-L-prolyl-L-leucylglycine amide (XI). In the new reaction steps N,N′-dicyclohexylcarbodiimide was used as sole coupling agent in combination with a variety of blocking groups. The conversion of XI into the pituitary hormone oxytocin is known. |
| Databáze: | OpenAIRE |
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