Encefalopatía subaguda reversible por metotrexato: notificación de un caso pediátrico
| Autor: | Daniela Font, Ariel Cheistwer, Lucía Astorquizaga, Florencia Palmieri, Florencia Marin |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Chemotherapy
medicine.medical_specialty business.industry medicine.medical_treatment Encephalopathy Neurotoxicity medicine.disease Gastroenterology Hemiparesis Internal medicine Pediatrics Perinatology and Child Health medicine Mucositis Methotrexate medicine.symptom business Adverse effect Stroke medicine.drug |
| Zdroj: | Archivos Argentinos de Pediatria. 119 |
| ISSN: | 0325-0075 |
| DOI: | 10.5546/aap.2021.e550 |
| Popis: | Leukemias are the most frequent malignant neoplasms in childhood; acute lymphoblastic leukemia (ALL) is the most frequent. The addition of intrathecal methotrexate to chemotherapy regimens has been beneficial in preventing relapse to the central nervous system and avoiding the use of radiation therapy. Due to its mechanism of action, by inhibiting the enzyme dihydrofolate reductase, when it is used systemically, it has multiple expected adverse effects such as mucositis, myelosuppression and it has also been observed after intrathecal administration or high intravenous doses, acute, subacute neurotoxicity where stroke like syndrome is found. We present an 11-year-old patient diagnosed with T-ALL, who manifested after 8 days of intrathecal administration of methotrexate, faciobrachial hemiparesis and acute onset expression aphasia. The diagnosis of subacute encephalopathy reversible by methotrexate was reached by excluding other Encefalopatia subaguda reversible por metotrexato: notificacion de un caso pediatrico Methotrexate-induced stroke-like syndrome: A pediatric case report more frequent pathologies and the typical evolution, with spontaneously ad integrum resolution of the symptoms. |
| Databáze: | OpenAIRE |
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