Antihyperlipidaemic and anti-atherosclerotic activities of aqueous leaf extract of L. africana in streptozotocin induced diabetic rats
| Autor: | F B Miikue-Yobe Togenu, A Uwakwe Augustine, O Akaninwor Joyce, Felix-Samuel Barisi |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Aqueous solution medicine.diagnostic_test business.industry 030111 toxicology Pharmacology Streptozotocin medicine.disease 03 medical and health sciences chemistry.chemical_compound High-density lipoprotein chemistry Anti atherosclerotic Diabetes mellitus Low-density lipoprotein medicine Pharmacology (medical) Lipid profile business Complication medicine.drug |
| Zdroj: | African Journal of Biochemistry Research. 10:20-24 |
| ISSN: | 1996-0778 |
| DOI: | 10.5897/ajbr2015.0866 |
| Popis: | Hyperlipidaemia is a usual and life threatening complication of diabetes mellitus. Consequently, a good anti-diabetic agent should reduce the progression of this complication. In view of this, the anti-hyperlipidaemic and anti-atherogenic activities of aqueous extract of Lasianthera africana was studied in streptozotocin induced diabetic rats. Extract treatment was administered at a dose of 1ml of 180 mg/ml of extract per kg body weight once daily for three weeks (21 days). Blood samples were collected thereafter by cardiac puncture for the analysis of lipid profile after the rats were exposed to chloroform vapour for 5 min. Results show that extract treatment caused significant (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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