P1568 Echocardiographic changes and ventricular mechanics in the indeterminate form of chagas disease

Autor: D F Brindeiro-Filho, Deborah Costa Lima Araujo, J M Del Castillo, Eugenio Soares de Albuquerque, Jonny Vitor Diniz, Katarina Barros Oliveira, Carlos Antonio da Mota Silveira, Antônia Dulcineide Medeiros Sena, Carlos Mazzarollo, M P C Alencar
Rok vydání: 2020
Předmět:
Zdroj: European Heart Journal - Cardiovascular Imaging. 21
ISSN: 2047-2412
2047-2404
DOI: 10.1093/ehjci/jez319.988
Popis: Introduction According to the WHO, Chagas disease affects 8 to 10 million people, mainly in the Americas and in some European countries, with more than 10 thousand annual deaths. It presents an acute phase followed by a chronic, categorized as indeterminate, cardiac or digestive forms. After infestation, most patients remain asymptomatic, but 40% progress to symptomatic form at the rate of 1.8 to 5% patients/year. Evidence of myocardial fibrosis in 41% of these patients was found by magnetic resonance imaging. Objective To evaluate, by echocardiography, patients with Chagas disease, indeterminate phase, analysing dimensions, function and parameters of deformation and mechanical dispersion in left and right cardiac cavities. Method The study included 44 asymptomatic patients, 36 female, mean age 51 ± 10 years with positive Chagas serology and a control group of 44 healthy individuals, 35 female, mean age 52 ± 10 years. Left and right cavitary dimensions were evaluated, systolic and diastolic function, global myocardial deformation and mechanical dispersion. The groups were compared by the paired "t" test with significance level Results Demographic data (age, body surface area) with no significant differences. Left ventricular (LV) diameters (p Conclusion Asymptomatic patients with Chagas disease (undetermined phase), when compared with healthy individuals of the same age group, presented larger cavitary diameters, diastolic disfunction and, deformation parameters of the left and right ventricles, with increased mechanical dispersion in both chambers. These data seem to corroborate recent results obtained by magnetic resonance imaging with gadolinium, suggesting areas of myocardial fibrosis in these patients.
Databáze: OpenAIRE
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