A prospective controlled study of luteal and endometrial abnormalities in an infertile population
| Autor: | D. Lynn Loriaux, George R. Merriam, Marcelo C. Batista, Maria J. Merino, Lynnette K. Nieman, Tannia P. Cartledge, Ann W. Zellmer |
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| Rok vydání: | 1996 |
| Předmět: |
Infertility
Gynecology medicine.medical_specialty education.field_of_study medicine.diagnostic_test business.industry Population Obstetrics and Gynecology Luteal phase medicine.disease Endometrium Human chorionic gonadotropin medicine.anatomical_structure Reproductive Medicine Medicine Outpatient clinic business education Corpus luteum Endometrial biopsy |
| Zdroj: | Fertility and Sterility. 65:495-502 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/s0015-0282(16)58143-6 |
| Popis: | Objective To investigate whether luteal and endometrial abnormalities occur more frequently in an infertile population and thus contribute to infertility. Design Prospective controlled clinical study. Setting Outpatient clinic in an academic research institution. Participants Thirty-three fertile controls and 31 infertile women without ovulatory disorders, tubal disease, or male factors. Interventions All women underwent an endometrial biopsy 9 days after the LH surge followed by an IM injection of 5,000 IU hCG. Blood samples were drawn immediately before hCG administration for serum P and placental protein 14 (PP14) measurements, at 6 hours after hCG stimulation for serum P concentrations, and on day 5 after hCG administration for serum PP14 levels. Main Outcome Measures Histologic dating of the endometrium and serum P and PP14 measurements. Results Abnormal endometrial biopsies occurred more frequently in infertile (43%) than in fertile women (9%). Except for one case, these specimens were not associated with low hCG-stimulated P levels. Serum PP14 measurements varied widely and did not discriminate subjects with abnormal endometrial development. Conclusions Disruption of endometrial maturation without a concomitant defect of the corpus luteum occurs more frequently in an infertile population and thus may contribute to infertility. |
| Databáze: | OpenAIRE |
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