FURTHER OBSERVATIONS ON THE EXPERIMENTAL TRANSMISSION OF CREUTZFELDT-JAKOB DISEASE FROM MAN TO SQUIRREL AND SPIDER MONKEYS
| Autor: | Roy O. Weller, D. P. Grant, I. Zlotnik, A. D. Dayan, C. J. Earl, L. S. Illis |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pathology
medicine.medical_specialty Spider Histology genetic structures Transmission (medicine) animal diseases Squirrel monkey Disease Biology Status spongiosus biology.organism_classification complex mixtures Pathology and Forensic Medicine Incubation period nervous system Neurology Physiology (medical) Female patient medicine sense organs Neurology (clinical) |
| Zdroj: | Neuropathology and Applied Neurobiology. 2:125-130 |
| ISSN: | 1365-2990 0305-1846 |
| Popis: | Inoculation of brain material from three female patients with Creutzfeldt-Jakob disease into squirrel and spider monkeys produced an experimental neurological disease similar to Creutzfeldt-Jakob disease in all the inoculated animals. The incubation period in squirrel monkeys varied from 17 to 29 months, but in the spider monkeys all the animals developed the disease between 19 and 22 months following inoculation. The early clinical signs were more readily recognized in squirrel monkeys than in spider monkeys. Itch and rubbing was a characteristic feature in all but one squirrel monkey, but it was absent in spider monkeys. The pathological change, in the form of widespread status spongiosus in the brain, as a rule was of greater severity in spider than in squirrel monkeys. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text