Aldosterone-Related Myocardial Extracellular Matrix Expansion in Hypertension in Humans
| Autor: | Helena Pereira, Michel Azizi, Elie Mousseaux, Gilles Soulat, Laurence Amar, Zainab Raissouni, Alban Redheuil, Dominique Helley, Jean-Louis Paul, Nadjia Kachenoura, Aurélien Lorthioir, Rosa Vargas-Poussou, Anne Blanchard |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Aldosterone business.industry 030204 cardiovascular system & hematology medicine.disease Essential hypertension Hyperaldosteronism 030218 nuclear medicine & medical imaging Muscle hypertrophy 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Primary aldosteronism Endocrinology Blood pressure chemistry Interquartile range Internal medicine Medicine Radiology Nuclear Medicine and imaging Myocardial fibrosis Cardiology and Cardiovascular Medicine business |
| Zdroj: | JACC: Cardiovascular Imaging. 13:2149-2159 |
| ISSN: | 1936-878X |
| DOI: | 10.1016/j.jcmg.2020.06.026 |
| Popis: | Objectives This study sought to assess the respective effects of aldosterone and blood pressure (BP) levels on myocardial fibrosis in humans. Background Experimentally, aldosterone promotes left ventricular (LV) hypertrophy, and interstitial myocardial fibrosis in the presence of high salt intake. Methods The study included 20 patients with primary aldosteronism (PA) (high aldosterone and high BP), 20 patients with essential hypertension (HTN) (average aldosterone and high BP), 20 patients with secondary aldosteronism due to Bartter/Gitelman (BG) syndrome (high aldosterone and normal BP), and 20 healthy subjects (HS) (normal aldosterone and normal BP). Participants in each group were of similar age and sex distributions, and asymptomatic. Cardiac magnetic resonance including cine and T1 mapping was performed blind to the study group to quantify global LV mass index, as well as intracellular mass index and extracellular mass index considered as a measure of myocardial fibrosis in vivo. Results Median plasma aldosterone concentration was as follows: PA = 709 pmol/l (interquartile range [IQR]: 430 to 918 pmol/l); HTN = 197 pmol/l (IQR: 121 to 345 pmol/l); BG = 297 pmol/l (IQR: 180 to 428 pmol/l); and HS = 105 pmol/l (IQR: 85 to 227 pmol/l). Systolic BP was as follows: PA = 147 ± 15 mm Hg; HTN = 133 ± 19 mm Hg; BG = 116 ± 9 mm Hg; and HS = 117 ± 12 mm Hg. LV end-diastolic volume showed underloading in BG and overloading in patients with PA (63 ± 13 ml/m2 vs. 82 ± 15 ml/m2; p Conclusions Only primary pathological aldosterone excess combined with high BP increased both extracellular myocardial matrix and intracellular mass. Secondary aldosterone excess with normal BP did not affect extracellular myocardial matrix. (Study of Myocardial Interstitial Fibrosis in Hyperaldosteronism; NCT02938910 ). |
| Databáze: | OpenAIRE |
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