Epigenetics and eating disorders
| Autor: | H. Frieling, V. Buchholz |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
050103 clinical psychology
medicine.medical_specialty Bulimia nervosa digestive oral and skin physiology 05 social sciences Anorexia medicine.disease behavioral disciplines and activities Energy homeostasis 030227 psychiatry 03 medical and health sciences Malnutrition Eating disorders 0302 clinical medicine Anorexia nervosa (differential diagnoses) Binge-eating disorder mental disorders medicine 0501 psychology and cognitive sciences medicine.symptom Psychiatry Psychology Dieting |
| DOI: | 10.1016/b978-0-12-800226-1.00015-0 |
| Popis: | Eating disorders like anorexia nervosa, bulimia nervosa, and binge eating disorder are common, severe, and often chronic psychiatric disorders. During the last years increasing knowledge about developmental risk factors, especially regarding pre-, peri-, and postnatal events, early life stress, and childhood maltreatment has been gathered. Dieting and malnutrition have been shown to impair one carbon (C1) metabolism thereby diminishing the patients’ possibilities to cope with changes in the energy metabolism. Several candidate gene studies and first genome-wide analyzes have shown alterations in DNA methylation in anorexia and to lesser extent bulimia nervosa. In this chapter we provide an epigenetically informed model of eating disorders, which integrates most of the current biological models of eating disorders and that may provide a rationale for further research and also for specific therapeutic aspects. |
| Databáze: | OpenAIRE |
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