| Autor: |
Siew Hua Gan, Hasnan Jaafar, Kuttulebbai N. S. Sirajudeen, Suk Peng Tang, Siti Amrah Sulaiman |
| Rok vydání: |
2017 |
| Předmět: |
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| Zdroj: |
International Journal of Pharmacy and Pharmaceutical Sciences. 9:319 |
| ISSN: |
0975-1491 |
| DOI: |
10.22159/ijpps.2017v9i2.15466 |
| Popis: |
Objective: The objective of this research was to investigate the possible protective effect of Tualang honey (TH) in acute paraquat (PQ) toxicity in rats.Methods: A total of 48 male Sprague-Dawley rats aged eight weeks old were used. Oral PQ and TH were administered at 225 mg/kg and 0.2 g/kg, respectively. The effects of single and multiple TH treatmentson PQ-intoxicated rats were then investigated. Single TH treatment groups received TH at 0.5 (PQ+TH0.5h), 2 (PQ+TH2h) or 6 (PQ+TH6h) hours following PQ administration. Multiple TH treatment groups received TH at 0.5, 2 and 6 h (PQ+THtrp) or further daily treatment for the following six days (PQ+TH7d) after PQ administration (n=6 per group). The survival time of the rat was recorded until day 28 before sacrifice, which was followed by a histological examination.Results: Treatment with TH did not improve the survival rate of PQ-intoxicated rats. However, the median survival time of rats that received multiple TH treatments was significantly longer compared to that of the PQ+TH6h group. TH treatment was found to improve the histological outcomes of PQ-intoxicated rats, particularly in the lungs.Conclusion: Our findings suggest the potential role of honey in delaying the toxic effects of PQ. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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