Brahmi herbal drink mitigates aluminium chloride induced cognitive impairments
| Autor: | T. Mohan Manu, M. D. Pandareesh, N. Roopa, T. Anand, N. Nagaraju, Farhath Khanum, N. Madhukar |
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| Rok vydání: | 2017 |
| Předmět: |
Elevated plus maze
Antioxidant Aché medicine.medical_treatment Morris water navigation task Pharmacology Neuroprotection General Biochemistry Genetics and Molecular Biology language.human_language Nitric oxide Lipid peroxidation chemistry.chemical_compound Nutraceutical chemistry language medicine General Pharmacology Toxicology and Pharmaceutics General Agricultural and Biological Sciences |
| Zdroj: | Defence Life Science Journal. 2:152 |
| ISSN: | 2456-0537 2456-379X |
| Popis: | Aluminium chloride (AlCl3) is neurotoxic and has been proposed to be one of the environmental factors responsible for neurodegenerative disease like Alzheimer’s and Parkinson’s disorders. It also causes learning and memory deficit. Bacopa monniera is well known for its memory enhancing property in traditional Indian system of medicine. In the present investigation we aim to evaluate cognitive-enhancing and neuromodulatory property of brahmi herbal drink (BHD), a nutraceutical product from Bacopa monniera extract. BHD was evaluated for physicochemical, sensory attributes and stability studies. Overall acceptability of BHD was good according to hedonic scale/ratings. Stability of the drink is for 6 months without losing its activity. Further, cognitive enhancing and neuromodulatory propensity of BHD was evaluated against AlCl3 treatment in rats. Administration of AlCl3 (100 mg/kg) daily for 23 days significantly increased cognitive impairment as evaluated in elevated plus maze (EPM) and Morris water maze (MWM) tests. BHD supplementation improved cognitive ability by decreasing the transfer and escape latency of EPM and MWM tests respectively. Our results further elucidate that BHD supplementation decreased acetylcholine esterase activity and nitric oxide levels by down-regulating AChE and iNOS expression respectively. BHD supplementation showed it neuroprotective efficacy by up-regulating BDNF expression. AlCl3 induced lipid peroxidation and reactive oxygen species generation was significantly alleviated by BHD and restored antioxidant status levels. All these results demonstrated the cognitive-enhancing and neuromodulatory potential of BHD in counteracting the damage inflicted by AlCl3 on rat brain. |
| Databáze: | OpenAIRE |
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