In vitro antioxidants and haematological and nephroprotective effects of biscuits produced from three medicinal flour blends fed to high-fat diet/streptozotocin (STZ)-induced diabetic rats

Autor: Matthew Olusola Oluwamukomi, J. O. Agbede, Ganiyu Oboh, Mopelola Ajoke Sodipo
Rok vydání: 2020
Předmět:
Zdroj: Comparative Clinical Pathology. 29:1137-1145
ISSN: 1618-565X
1618-5641
DOI: 10.1007/s00580-020-03161-5
Popis: This study investigated the in vitro antioxidants and haematological and nephroprotective effects of biscuits produced from three medicinal flour blends fed to high-fat diet/streptozotocin (STZ)-induced diabetic rats. The biscuits were produced at different proportions of flour blends. The total phenol and flavonoid, FRAP, DPPH, and α-amylase and glucosidase of the biscuits were determined. The White Albino Wistar rats were induced with streptozotocin (STZ) and fed with the formulated biscuits for 14 days. The animals were sacrificed, and blood was obtained and used to determine haematological parameter. Then, the liver and kidney were examined for histopathological parameter. The formulated biscuits possessed phenolic content, reduced Fe2+ to Fe3+, and scavenge DPPH and inhibited α-amylase and glucosidase activities. It was observed that the haematological parameters of the treated diabetic rats fed with formulated biscuits improved significantly compared with that of the untreated STZ-induced diabetic rats. The creatinine, urea, and uric acid significantly reduced in treated rats with formulated biscuits. The formulated biscuits lowered the blood glucose level in the rats. Therefore, this formulated biscuit may be useful in the management of diabetes.
Databáze: OpenAIRE
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