Gene Expression Analysis Identifies Cholesterol Metabolism Dysregulation in Hippocampus of Phenytoin-Resistant Pentylenetetrazol-Kindled Epileptic Mice
| Autor: | Sridhar Amalakanti, Nitin Khandelwal, N. V. Sundarachary, Unis Ahmad Bhat, Arvind Kumar, Madhavi B. Mylavarapu, Sumana Chakravarty |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microarray Microarray analysis techniques Hippocampus Pharmacology Biology medicine.disease Drug Resistant Epilepsy 03 medical and health sciences Cellular and Molecular Neuroscience Epilepsy 030104 developmental biology 0302 clinical medicine Neurology Convulsion Gene expression medicine Molecular Medicine Pentylenetetrazol medicine.symptom 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | NeuroMolecular Medicine. 23:485-490 |
| ISSN: | 1559-1174 1535-1084 |
| DOI: | 10.1007/s12017-021-08648-0 |
| Popis: | Pharmaco-resistant Epilepsy has been a major challenge for medical interventions in controlling seizures. To date, up to 33% of the patients with epilepsy do not show adequate response to anti-epileptic drugs even after prolonged combinatorial drug usage. Using microarray, this study explores the changes in hippocampal gene expression in the phenytoin-resistant pentylenetetrazol (PTZ)-kindled mouse model of epilepsy. Our results from mRNA microarray analysis show distinct gene expression profiles in the hippocampus of phenytoin-resistant and sensitive mice. Pathway enrichment analysis showed differential expression of genes involved in cholesterol biosynthesis in phenytoin-resistant and sensitive mice. |
| Databáze: | OpenAIRE |
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