Structural Isomerization of 2-Anilinonicotinic Acid Leads to a New Synthon in 6-Anilinonicotinic Acids

Autor:	Faquan Yu, Conggang Li, Sean Parkin, Tonglei Li, Sihui Long, Mingtao Zhang, Danrui Xu, Siqing Peng
Rok vydání:	2018
Předmět:	Stereochemistry Chemistry Synthon General Materials Science 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 0210 nano-technology Condensed Matter Physics 01 natural sciences Isomerization 0104 chemical sciences
Zdroj:	Crystal Growth & Design. 18:4849-4859
ISSN:	1528-7505 1528-7483
DOI:	10.1021/acs.cgd.8b00840
Popis:	Through structural modification of 2-anilinonicotinic acid by isomerization, a new synthon, acid-aminopyridine, is created, and the two original synthons, i.e., the acid–acid homosynthon and acid–pyridine heterosynthon are no longer observed in the newly designed 6-anilinonicotinic acids. The new synthon has a hydrogen-bond strength rivaling that of the acid–acid homosynthon and the acid–pyridine heterosynthon, as suggested by theoretical calculations, which explains its formation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78df07ae8d12ce3b8727e33c5271acf6 https://doi.org/10.1021/acs.cgd.8b00840 Zobrazit plný text záznamu