Studies on Digitalis Glycosides. XVII. Transformation of Cardenolides by Microorganisms. (3). 1β, 7β-Dihydroxy-digitoxigenin and 5β, 7β-Dihydroxydigitoxigenin

Autor:	Hiroshi Ishii, Yoshio Nozaki, Daisuke Satoh, Tamotsu Okumura
Rok vydání:	1963
Předmět:	biology Stereochemistry Microorganism General Chemistry General Medicine biology.organism_classification chemistry.chemical_compound Transformation (genetics) Digitoxigenin Aglycone Absidia chemistry Drug Discovery Organic chemistry DIGITALIS GLYCOSIDES
Zdroj:	Chemical and Pharmaceutical Bulletin. 11:156-159
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.11.156
Popis:	The structure and configuration of two kinds of dihydroxyl derivatives obtained by microbiological transformation of digitoxigenin with Absidia orchidis were discussed. One of them was shown to be 1β, 7β-dihydroxydigitoxigenin and the other 5β, 7β-dihydroxydigitoxigenin. This represents the first instance of the introduction of two hydroxyl groups into a cardiac aglycone by microbial oxidation.
Databáze:	OpenAIRE
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