The exon 3-retaining and the exon 3-deleted forms of the growth hormone-binding protein (GHBP) in human serum are regulated differently

Autor:	A. Bosse-Henck, Wieland Kiess, B. Dehmel, Juergen Kratzsch, C.D. Pflaum, Zida Wu, Reuter W, Christian J. Strasburger
Rok vydání:	2001
Předmět:	Gene isoform medicine.medical_specialty Apolipoprotein B Endocrinology Diabetes and Metabolism Binding protein Growth hormone receptor Biology Exon Endocrinology Growth hormone-binding protein Internal medicine Blood plasma Extracellular medicine biology.protein
Zdroj:	Clinical Endocrinology. 54:61-68
ISSN:	0300-0664
DOI:	10.1046/j.1365-2265.2001.01177.x
Popis:	Recently, two isoforms of the growth hormone-binding protein (GHBP), which is identical with the extracellular domain of the growth hormone receptor (GHR), have been described. One isoform contains the exon 3 (E3(+)GHBP) and one excludes the exon 3 (E3(–)GHBP). The distribution of both isoforms in peripheral blood and their functional relevance is so far unknown. To study the molecular distribution of both species we have analysed sera of 141 subjects with average weight, overweight and obesity by newly developed immunoassays. The relationship between the different molecular forms of GHBP and specific parameters of body composition as well as risk factors of metabolic disturbances, were then examined. The extracellular domain of the exon 3-retaining and -deleted isoforms of the GHR are released as E3(+)GHBP and E3(–)GHBP into the peripheral circulation. Furthermore, both molecular species do not show any correlation to each other (r = 0·67) and their relative proportion in blood is gender-dependent with a higher E3(–)GHBP proportion in females (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78da31ef50959385dd0ced3e4f032fb0 https://doi.org/10.1046/j.1365-2265.2001.01177.x Zobrazit plný text záznamu Plný text