The ketogenic diet inhibits the mammalian target of rapamycin (mTOR) pathway
| Autor: | Sharon S. McDaniel, Liu Lin Thio, Nicholas Rensing, Kelvin A. Yamada, Michael Wong |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment RPTOR Kainate receptor Status epilepticus Biology Pharmacology Epileptogenesis Endocrinology Neurology Internal medicine medicine TOR Serine-Threonine Kinases Neurology (clinical) Signal transduction medicine.symptom PI3K/AKT/mTOR pathway Ketogenic diet |
| Zdroj: | Epilepsia. 52:e7-e11 |
| ISSN: | 0013-9580 |
| DOI: | 10.1111/j.1528-1167.2011.02981.x |
| Popis: | The ketogenic diet (KD) is an effective treatment for epilepsy, but its mechanisms of action are poorly understood. We investigated the hypothesis that the KD inhibits mammalian target of rapamycin (mTOR) pathway signaling. The expression of pS6 and pAkt, markers of mTOR pathway activation, was reduced in hippocampus and liver of rats fed KD. In the kainate model of epilepsy, KD blocked the hippocampal pS6 elevation that occurs after status epilepticus. Because mTOR signaling has been implicated in epileptogenesis, these results suggest that the KD may have anticonvulsant or antiepileptogenic actions via mTOR pathway inhibition. |
| Databáze: | OpenAIRE |
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