Fully automated synthesis of O-(2′-[18F]fluoroethyl)-l-tyrosine ([18F]FET) using solid phase extraction (SPE) purification with neutral alumina
| Autor: | Sushant Roy, Yogita Pawar, Amit Kumar, Pradip Chaudhari, M.G.R. Rajan, N. Lakshminarayanan |
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| Rok vydání: | 2016 |
| Předmět: |
Chromatography
Chemistry Elution Health Toxicology and Mutagenesis Phosphate buffered saline Public Health Environmental and Occupational Health Pollution 030218 nuclear medicine & medical imaging Analytical Chemistry 03 medical and health sciences 0302 clinical medicine Alumina column Nuclear Energy and Engineering Fully automated 030220 oncology & carcinogenesis 18F-fluoroethyl-L-tyrosine Yield (chemistry) Radiology Nuclear Medicine and imaging Solid phase extraction Enantiomer Spectroscopy |
| Zdroj: | Journal of Radioanalytical and Nuclear Chemistry. 310:991-999 |
| ISSN: | 1588-2780 0236-5731 |
| Popis: | [18F]FET was synthesized using O-(2′-tosyloxyethyl)-N-trityl-l-tyrosine-tert-butyl ester (TET) precursor. SPE purification of [18F]FET, after radio-synthesis, using neutral alumina column was satisfactory, with radiochemical and enantiomeric purity of >99 %. Decay-uncorrected synthesis yield with 8 mg TET was 19.07 ± 1.3 and 8.76 ± 0.46 % when eluted in 35 and 17 mL of buffered saline, respectively, for practical considerations. O-(2′-hydroxyethyl)-l-tyrosine formed during synthesis could be reduced nine-fold to |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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