Cardiac 18F-fluorodeoxyglucose uptake on positron emission tomography after thoracic stereotactic body radiation therapy
| Autor: | Gregory W. Gladish, Ritsuko Komaki, Jose Banchs, Joe Y. Chang, Jeremy J. Erasmus, James W. Welsh, Daniel R. Gomez, Neal Rebueno, Jaden D. Evans |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Fluorodeoxyglucose
medicine.medical_specialty Lung medicine.diagnostic_test business.industry Stereotactic body radiation therapy medicine.medical_treatment Fdg uptake Hematology Radiation therapy medicine.anatomical_structure Oncology Positron emission tomography medicine Retrospective analysis Radiology Nuclear Medicine and imaging Radiology Nuclear medicine business medicine.drug |
| Zdroj: | Radiotherapy and Oncology. 109:82-88 |
| ISSN: | 0167-8140 |
| Popis: | Background and purpose Previous studies have shown that increased cardiac uptake of 18 F-fluorodeoxyglucose (FDG) on positron emission tomography (PET) may be an indicator of myocardial injury after radiotherapy. We reviewed patients treated with thoracic stereotactic body radiation therapy (SBRT) and established correlations between SBRT dose and observed changes in cardiac FDG–PET uptake. Material and methods Retrospective analysis identified 39 patients that were treated with SBRT for lung tumors close to the heart. Patients were grouped according to whether or not they had changes in cardiac FDG–PET uptake within the planned SBRT field. Results At a median follow-up interval of 39months (range, 6–81months), nine patients (23%) showed increased cardiac FDG uptake associated with the heart V 20 . Of the 19 patients who received 20Gy to ⩾5cm 3 of the heart, nine (47%) developed increased FDG uptake (vs. 0% for the 20 patients who received 20Gy to 3 ) ( P =0.0004), all within the 20-Gy isodose line. Patients with hypercholesterolemia prior to SBRT were also more likely to show increased cardiac FDG uptake ( P =0.0190). Conclusion Increased FDG uptake in the heart after SBRT was observed when the 20Gy isodose line exceeded 5cm 3 of the heart. |
| Databáze: | OpenAIRE |
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