Dimensional Analysis and Constitutive Equations of Quantitative Microdialysis

Autor:	CF Chen
Rok vydání:	2017
Předmět:	Physics::Fluid Dynamics symbols.namesake Microdialysis Constitutive equation symbols Reynolds number Sampling (statistics) Area ratio Mechanics Capillary perfusion Dimensionless quantity Mathematics
Zdroj:	Insights of Biomedical Research. 1
ISSN:	2642-4576
DOI:	10.36959/584/437
Popis:	As a membrane-based sampling technique microdialysis can be quantified by the relative recovery and the time-to-reach-the-steady-state in sampling. In this paper dimensional analysis is applied to show that the performance can be collectively determined by three dimensionless numbers, the Peclet and Reynolds numbers of the perfusion flow and the membrane-to-channel area ratio. With three dimensionless numbers in place, combinatorial simulations were conducted to calculate the relative recovery and time-to-reach-the-steady-state of microdialysis under various operation conditions at different scales.
Databáze:	OpenAIRE
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