Studies on Insecticides. V. Synthesis of 2-Piperidone Derivatives

Autor:	Torizo Takahashi, Kazuo Kariyone
Rok vydání:	1960
Předmět:	chemistry.chemical_compound Acetic anhydride Reaction temperature Chemistry Drug Discovery Pyridine Organic chemistry Piperidine derivative General Chemistry General Medicine Methanol Carbonyl group Raney nickel
Zdroj:	Chemical and Pharmaceutical Bulletin. 8:1106-1109
ISSN:	1347-5223 0009-2363
DOI:	10.1248/cpb.8.1106
Popis:	Hydrogenation of 2 (1H)-pyridones was carried out in methanol over Raney nickel at 120 atm. and 200∼240°and gave 2-piperidone derivatives. When the reduction temperature was raised to 280°, hydrogenation of carbonyl group took place, followed by N-methylation of the resulting piperidine derivative was observed. On the other hand, when the reaction temperature was kept below 180°, the starting material was recovered unchanged. By the action of acetic anhydride on 4-ethylpyridine 1-oxide, 4-(1-hydroxyethyl) pyridine and 4-ethyl-3-hydroxypyridine were obtained, while 4-methoxycarbonylpyridine 1-oxide gave 4-methoxycarbonyl-2 (1H)-pyridone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78b8c6d57f32d9a2914c9b77ca265ca5 https://doi.org/10.1248/cpb.8.1106 Zobrazit plný text záznamu