Role of intercellular adhesion molecules and antibodies to oxidized LDL in pathogenesis of cardiovascular diseases under mercury exposure
| Autor: | Irina V. Kudaeva, Olga V. Naumova, L. B. Masnavieva, O. A. Dyakovich |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Cardiovascular pathology Health Toxicology and Mutagenesis chemistry.chemical_element 010501 environmental sciences 01 natural sciences 03 medical and health sciences Internal medicine medicine In patient Endothelial dysfunction Risk factor 0105 earth and related environmental sciences biology business.industry Cell adhesion molecule Public Health Environmental and Occupational Health General Medicine medicine.disease Pollution Mercury (element) 030104 developmental biology Endocrinology chemistry biology.protein Antibody business Oxidized ldl |
| Zdroj: | Hygiene and sanitation. 99:1120-1126 |
| ISSN: | 2412-0650 0016-9900 |
| DOI: | 10.47470/0016-9900-2020-99-10-1120-1126 |
| Popis: | Introduction. Exposure to mercury and its compounds can be a risk factor for the development of cardiovascular diseases. The aim of the study is to investigate the levels of antibodies to oxidized LDL, intercellular adhesion molecules sICAM-1, sVCAM-1, and VEGF in individuals exposed to mercury. Material and Methods. A cross-sectional examination was carried out using biochemical methods in persons who have come into contact with metallic mercury with a work experience of more than five years, persons with a first established diagnosis of chronic mercury intoxication, and patients with chronic mercury intoxication in the long-term postexposure period. Results. In persons exposed to mercury with concomitant cardiovascular diseases, the level of sVCAM-1 differed depending on the presence/absence of intoxication and acquired maximum values in its long-term period, while the concentrations of sICAM-1 and antibodies to oxidized LDL did not differ significantly. In the groups without cardiovascular pathology exposed to mercury, the concentration of sVCAM-1 was higher in patients with intoxication, and sICAM-1 was 1.5-2 times lower when compared with experienced individuals, the level of antibodies to oxidized LDL was maximum in the presence of intoxication in its initial period. Discussion. The progression of chronic mercury intoxication is accompanied by an increase in the level of sVCAM-1, and a gradual decrease in the content of sICAM-1 to reference values. Trained workers were found to have elevated sICAM-1 levels. Conclusion. The role of antibodies to oxidized LDL, intercellular adhesion molecules is their multidirectional participation in the mechanisms that inhibit or contribute to the formation of cardiovascular pathology in individuals exposed to mercury. |
| Databáze: | OpenAIRE |
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