Sex hormones and the regulation of erythroid spleen colonies development of fetal liver origin

Autor:	I Bleiberg, G Perah
Rok vydání:	1975
Předmět:	Immunology Cell Biology Hematology Biochemistry
Zdroj:	Blood. 45:511-515
ISSN:	1528-0020 0006-4971
Popis:	The development of erythroid colonies of fetal liver hemopoietic cell origin in adult irradiated polycythemic mice was studied. It was found that orchidectomy sharply reduced the number of erythroid colonies developed in the spleen of these polycythemic male recipients. Estrogen injection to the orchidectomized polycythemic recipient did not further decrease the number of erythroid colonies developed. It is concluded that the development of erythroid colonies of fetal liver origin in polycythemic male recipients is maintained mainly by testicular testosterone. The complete suppression of these colonies in female recipients does not seem to be a result of inhibition by estrogen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78b05f36a58899b61c57ea44856eb8e9 https://doi.org/10.1182/blood.v45.4.511.bloodjournal454511 Zobrazit plný text záznamu