Proteomics in discovery of hepatocellular carcinoma biomarkers

Autor:	Jun-hua Lu, Ping Liao, Bao-hai Liu, Liang Zhu, Zhan-feng Wang, Wen-jing Wang, Lijie Liu, Song-tao Li, Cheng Wu
Rok vydání:	2007
Předmět:	Cancer Research Pathology medicine.medical_specialty education.field_of_study business.industry Population medicine.disease Proteomics Chronic liver disease digestive system diseases Oncology Medicine public health Hepatocellular carcinoma medicine Biomarker (medicine) business education
Zdroj:	Chinese Journal of Cancer Research. 19:159-164
ISSN:	1993-0631 1000-9604
DOI:	10.1007/s11670-007-0159-5
Popis:	To discover new proteomic biomarkers of hepatocellular carcinoma. Surface enhanced laser desorption/ionization time-of-flight (SELDI-TOF) mass spectrometry was used to discover biomarkers for differentiating hepatocellular carcinoma and chronic liver disease. A population of 50 patients with hepatocellular carcinoma and 33 patients with chronic liver disease was studied. Twelve proteomic biomarkers of hepatocellular carcinoma were detected in this study. Three proteomic biomarkers were highly expressed in hepatocellular carcinoma and nine proteomic biomarkers were highly expressed in chronic liver disease. The most valuable proteomic biomarker with m/z=11498 had no similar diagnostic value as α-fetoprotein. Some of the twelve proteomic biomarkers may become new biomarkers of hepatocellular carcinoma.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78aacaba75dc23ec50a0ea20082612ee https://doi.org/10.1007/s11670-007-0159-5 Zobrazit plný text záznamu Full text from SpringerLink