Synthesis of amphiphilic copolymers based on dendritic polyethylene grafted by polyhydroxyethylmethacrylate and polyhydroxypropylmethacrylate and their use for construction of nanoparticles
| Autor: | Kateřina Nunvářová, Miroslav Šlouf, Jan Merna, Barbora Charvátová, Soňa Hermanová |
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| Rok vydání: | 2019 |
| Předmět: |
Materials science
Molar mass Polymers and Plastics Organic Chemistry Nile red General Physics and Astronomy Nanoparticle 02 engineering and technology Polyethylene 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Polyhydroxyethylmethacrylate 0104 chemical sciences chemistry.chemical_compound chemistry Chemical engineering Chain walking Amphiphile Materials Chemistry Copolymer 0210 nano-technology |
| Zdroj: | European Polymer Journal. 115:193-200 |
| ISSN: | 0014-3057 |
| DOI: | 10.1016/j.eurpolymj.2019.03.029 |
| Popis: | By grafting from approach amphiphilic grafted copolymers with a hydrophobic core based on dendritic polyethylene and hydrophilic grafts of polyhydroxyethylmethacrylate (PHEMA) and polyhydroxypropylmethacrylate (PHPMA) were synthesized by tandem chain walking copolymerization and ATRP. Copolymers with molar mass 160–1400 kg/mol and ∼50–90% of hydrophilic grafts were obtained. Core-shell nanoparticles with very narrow size distribution were prepared from the copolymers by solvent displacement method. Particles diameter was efficiently regulated by molar mass of the copolymers in the range of 60–180 nm. We demonstrated that these nanoparticles can act as nanocontainers for hydrophobic Nile red dye, achieving up to 25% encapsulation efficiency. Dendritic polyethylene (dPE) nanoparticles with biocompatible polar PHEMA and PHPMA shell can find application in nanocatalysis and cargo delivery. |
| Databáze: | OpenAIRE |
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