Protective effects ofStachys sieboldiiMIQ extract in SK-N-SH cells and its memory ameliorative effect in mice
| Autor: | Eun‐seon jeong, Youn-Soo Cha, Ravichandran Vijaya Abinaya, Mina Kim, Seung-je Lee |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pharmacology Stereochemistry Biophysics Hippocampus Cell Biology medicine.disease_cause Choline acetyltransferase 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry In vivo medicine Choline Cholinergic Neurotransmitter 030217 neurology & neurosurgery Oxidative stress Acetylcholine Food Science medicine.drug |
| Zdroj: | Journal of Food Biochemistry. 41:e12411 |
| ISSN: | 0145-8884 |
| DOI: | 10.1111/jfbc.12411 |
| Popis: | This work aims to evaluate the potential effect of Stachys sieboldii MIQ (SS) against oxidative stress induced by hydrogen peroxide (H2O2) in SK-N-SH cells and memory enhancement in ICR mice using the passive avoidance test. The effect of SS in cell proliferation was measured by BrdU incorporation assay with dosages of SS from 0 to 2 mg/mL. SS partially antagonized the effect of 150 μM H2O2 on cell proliferation. In vivo study, SS (100, 250, and 500 mg/kg) was administered orally to mice for 4 weeks. SS led to a significantly longer step-through latency time compared to control mice. Memory enhancing effect of SS (500 mg/kg) was also observed in amnesia model, SS escalate the fear memory (p |
| Databáze: | OpenAIRE |
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