O,O,O-Triphenylmonothiophosphat
| Autor: | Hartwig, Andrea, MAK Commission |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2021 |
| Předmět: |
Schilddrüsenkolloid
O O O-triphenyl monothiophosphate triphenoxy(sulfanylidene)-λ5-phosphane Phosphorthiosäure follikuläre Hypertrophie liver maximum concentration at the workplace thyroid peak limitation MAK‑Wert Triphenylphosphorthioat O O O-triphenyl thiophosphate Leber O O O-Triphenylmonothiophosphat phosphorothioic acid O O O-triphenyl ester Schilddrüse Spitzenbegrenzung O O O-triphenylester O O O-Triphenylthiophosphat MAK value thyroid follicle cell hypertrophy thyroid colloid hepatozelluläre Hypertrophie O O O-Triphenylmonothiophosphat hepatocellular hypertrophy Triphenoxy(sulfanyliden)-λ5-phosphan maximale Arbeitsplatzkonzentration triphenyl phosphorothioate |
| DOI: | 10.34865/mb59782d6_3or |
| Popis: | The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has evaluated O,O,O-triphenylmonothiophosphate [597-82-0] considering all toxicological end points. O,O,O-triphenylmonothiophosphate is not neurotoxic in hens and rats and not irritating to the eyes and skin of rabbits. In an oral 13-week toxicity study with rats, increased liver weights and hepatocellular hypertrophy in addition to follicle cell hypertrophy and altered colloid in the thyroid gland were observed at 200 mg/kg body weight and day. On the basis of the NOAEL of 39.5 mg/kg body weight and day, a maximum concentration at the workplace (MAK value) of 20 mg/m has been established. As its critical effect is systemic, O,O,O-triphenylmonothiophosphate has been assigned to Peak Limitation Category II. The default excursion factor of 2 has been set because its half-life is not known. O,O,O-triphenylmonothiophosphate was not found to be mutagenic in two tests with Salmonella and a mixture of triphenylthiophosphate and its butylated derivatives was not found to be clastogenic or mutagenic in vitro. In vivo genotoxicity tests and carcinogenicity studies have not been performed with O,O,O-triphenylmonothiophosphate. A screening study carried out according to OECD Test Guideline 421 to investigate the reproductive toxicity and toxicity of O,O,O-triphenylmonothiophosphate did not report any effects on perinatal reproduction; studies specifically investigating developmental toxicity are not available. The substance has therefore been assigned to Pregnancy Risk Group D. There are no studies which demonstrate that O,O,O-triphenylmonothiophosphate is sensitizing to the skin or airways. The substance does not penetrate the skin in toxicologically relevant amounts. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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