Enantioselective Dearomative Alkynylation of Chromanones: Opportunities and Obstacles

Autor:	Anita E. Mattson, Yong Guan, Tadas Buivydas, Remy F. Lalisse, Rameez Ali, Christopher M. Hadad
Rok vydání:	2022
Předmět:	Organic Chemistry Catalysis
Zdroj:	Synthesis. 54:4210-4219
ISSN:	1437-210X 0039-7881
DOI:	10.1055/a-1811-8075
Popis:	A catalytic and highly enantioselective dearomative alkynylation of chromanones has been discovered that enables the construction of biologically relevant tertiary ether stereogenic centers. This methodology is robust, accommodating a variety of alkynes and chromanones. More than 40 substrates tested gave rise to >90% ee. Computational studies have indicated that the optimal indanyl ligand identified for most cases likely affords a network of supportive, non-covalent interactions that drive the enantioselective nature of the reaction.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::789f7fcf56d2c1f8a5bd6bdf40688fe0 https://doi.org/10.1055/a-1811-8075 Zobrazit plný text záznamu