| Autor: |
Kui-Chung Lee, Elisabeth Trimble, V. H. Patterson, Geraldine Roberts |
| Rok vydání: |
1990 |
| Předmět: |
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| Zdroj: |
Amino Acids ISBN: 9789072199041 |
| DOI: |
10.1007/978-94-011-2262-7_78 |
| Popis: |
Spasticity is a part of the upper motor neurone syndrome in which there is a velocity-dependent increase in tone. It is easy to recognise but much more difficult to treat successfully. Despite the recent advance of intrathecal baclofen treatment [1] the need for a new oral antispastic agent still exists as conventional therapy is often limited by side-effects [2]. Glycine is an important inhibitory neurotransmitter in the spinal cord, [3] and it is diminished in the ventral gray matter of animals with spasticity [4]. Glycine, however crosses the blood-brain barrier poorly, and a possible precursor L-threonine has been used as treatment [5,6]; threonine crosses the blood-brain barrier more easily and may be converted to glycine by the enzyme serine hydroxymethyltransferase [7]. Systemic administration of L-threonine increases spinal cord glycine in rats [8]. In previous open studies, L-threonine has been given to patients with spasticity in doses ranging from 1.5 to 3 g/day. The lower dosage was ineffective but 3 g/day produced a modest effect. We therefore decided to test the antispastic effect of L-threonine by using higher doses than previous studies. We also monitored neurochemical changes by measuring CSF glycine and L-threonine during the different phases of the study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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