One-pot dehydrations using phenyl isothiocyanate

Autor:	George Majetich, Stephen Thompson, Thomas C. Irvin
Rok vydání:	2015
Předmět:	chemistry.chemical_classification Phenyl isothiocyanate Sodium Organic Chemistry chemistry.chemical_element Salt (chemistry) Alcohol medicine.disease Biochemistry Toluene chemistry.chemical_compound chemistry Drug Discovery Alkoxide medicine Organic chemistry Dehydration Chugaev elimination
Zdroj:	Tetrahedron Letters. 56:3326-3329
ISSN:	0040-4039
Popis:	Alcohols undergo dehydration in a one-pot procedure when the alkoxide, formed by treating the starting alcohol dissolved in toluene with NaH, reacts with phenyl isothiocyanate and the resulting sodium carbonimidothioate salt is heated overnight at 200 °C. The phenyl isothiocyanate dehydration yields are comparable to those obtained using the classical two-step Chugaev elimination conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::789393184e2bdcc404a5da6c88f5ec27 https://doi.org/10.1016/j.tetlet.2015.01.086 Zobrazit plný text záznamu Full Text from ScienceDirect