Relationship Between Serum Bilirubin Concentration and Inflammatory Cytokines in Victims Exposed to Sulfur Mustard
| Autor: | Roya Yaraee, Zuhair Mohammad Hassan, Mohammad Reza Vaez Mahdavi, Tooba Ghazanfari, Jalaleddin Shams, Nayere Askari, Mohammadreza Jalali-Nadoushan, Soghrat Faghihzadeh, Mohammad Reza Soroush |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030102 biochemistry & molecular biology business.industry Bilirubin Interleukin Sulfur mustard Context (language use) General Medicine 010501 environmental sciences medicine.disease 01 natural sciences Hemolysis Surgery Kowsar Proinflammatory cytokine 03 medical and health sciences chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Tumor necrosis factor alpha business 0105 earth and related environmental sciences |
| Zdroj: | Trauma Monthly. 22 |
| ISSN: | 2251-7472 2251-7464 |
| DOI: | 10.5812/traumamon.39192 |
| Popis: | Background: Despite observed post Sulfur Mustard (SM) exposure hemolysis, serum bilirubin concentration doesn’t significantly increase in SM-exposed casualties. The concentration of serum bilirubin can be related to serum levels of inflammatory cytokines. Objectives: In this study, the relationship between the serum levels of Interleukin (IL)-1α, IL-1β, IL-1Ra, Tumor Necrotizing Factor (TNF)-α and IL-6 with serum bilirubin concentration was investigated. Methods: Overall, 368 individuals, who were exposed to SM in 1986, and 127 non-exposed control participants were studied in the context of hematological factors, serum bilirubin and inflammatory cytokines. Total serum bilirubin and direct bilirubin were analyzed using an enzymatic method, while the inflammatory cytokines were evaluated by the enzyme linked immunosorbent assay (ELISA). Results: The concentration of inflammatory cytokines in the exposed group was significantly different compared to the control group, however the serum concentrations of total and direct bilirubin did not differ between the two groups. Among cytokines, other than the relationship between the IL-6 concentrations and bilirubin level, there were no significant correlations between the levels of other cytokines with direct and total bilirubin. Conclusions: Considering the lack of correlation between bilirubin concentrations and levels of inflammatory cytokines other than IL-6, we should identify other confounding factors for lack of increase in bilirubin in SM casualties, despite the observed hemolysis. |
| Databáze: | OpenAIRE |
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