Physiological Advantage of Phenotypic Heterogeneity in a Quorum-Sensing Population

Autor:	Supreet Saini, E. Rajeshkannan
Rok vydání:	2020
Předmět:	0303 health sciences 03 medical and health sciences Quorum sensing education.field_of_study Multidisciplinary 030306 microbiology Genetic heterogeneity Population Context (language use) Computational biology Biology education 030304 developmental biology
Zdroj:	Journal of the Indian Institute of Science. 100:485-496
ISSN:	0019-4964 0970-4140
DOI:	10.1007/s41745-020-00175-4
Popis:	Quorum sensing, or the ability of a population, to respond to an environmental cue in a coordinated manner has made fundamental changes about how we understand bacterial physiology. In this framework, a population, once it exceeds a certain threshold in size, and in the appropriate environmental conditions, coordinates expression of genes across individual members of the population in a fashion so that all individual members are in sync. This ability allows the population to accomplish tasks (like searching for nutrients in the surrounding environment) that would be difficult to perform, if undertaken by a single cell. In this context, quorum sensing is a homogenizing force in a population. However, in recent years, a number of studies have reported that quorum sensing can also lead to a heterogeneous response in terms of gene expression across the population. A discussion of the strategies which explain this heterogeneity in the population at a single-cell resolution is the focus of this review.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::78903612de7949082d851728ddacc76e https://doi.org/10.1007/s41745-020-00175-4 Zobrazit plný text záznamu Full text from SpringerLink