Synthesis of Indoles by Intermolecular Cyclization of Unfunctionalized Nitroarenes and Alkynes: One-Step Synthesis of the Skeleton of Fluvastatin

Autor:	Simone Fantauzzi, Fabio Ragaini, Mohamed Hagar, Sergio Cenini, Flavia Ventriglia
Rok vydání:	2009
Předmět:	chemistry.chemical_classification Indole test Organic Chemistry Alkyne chemistry.chemical_element Chemical synthesis Catalysis chemistry.chemical_compound chemistry Organic chemistry Physical and Theoretical Chemistry Dimethyl carbonate Selectivity Carbonylation Palladium
Zdroj:	European Journal of Organic Chemistry. 2009:2185-2189
ISSN:	1099-0690 1434-193X
Popis:	The addition of Ru3(CO)12, dimethyl carbonate, or both to the reaction mixture improves the selectivity of the palladium/phenanthroline-catalyzed reaction of nitroarenes, arylalkynes, and CO to give 3-arylindoles. When 4-fluorophenylacetylene and nitrobenzene are used as substrates, the indole skeleton of Fluvastatin and other pharmaceutically active compounds is obtained in one step.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::7887f188a043dcc1925b9c1835d76440 https://doi.org/10.1002/ejoc.200801274 Zobrazit plný text záznamu Plný text