Left Atrial Volume as a Biomarker of Target Organ Damage in Cardionephrology
| Autor: | Yitzhak Hadad, Shlomo Berliner, Moshe Iluz, Zach Rozenbaum, Tomer Ziv-Baran, Orit Kliuk Ben-Bassat, Yoav Granot, Galit Aviram |
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| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
Body surface area medicine.medical_specialty business.industry 030232 urology & nephrology Renal function Cardiorenal syndrome 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine medicine.disease Pulmonary embolism 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Ventricle Cardiac chamber Concomitant Internal medicine medicine Cardiology Cardiology and Cardiovascular Medicine business Kidney disease |
| Zdroj: | Chest. 154:893-903 |
| ISSN: | 0012-3692 |
| DOI: | 10.1016/j.chest.2018.05.017 |
| Popis: | Background Cardiac chamber size was previously studied by echocardiography, among patients with progressive kidney disease only. We aimed to explore the relations between all heart chamber volumes as assessed by CT pulmonary angiography and renal function, throughout all ranges. Methods Using a novel technology for automatic four-chamber volumetric analysis, we analyzed CT pulmonary angiography results for 748 consecutive patients (between January 1 and December 31, 2014) without pulmonary embolism, and correlated the chamber volumes, indexed to body surface area, with the estimated glomerular filtration rates (eGFRs). Results After adjustment for age, all cardiac chamber volumes aside from that of the left ventricle inversely correlated with the eGFR. For every 10-unit decrease in eGFR, the volume indices of the left atrium, right atrium, and right ventricle were larger by 3.1%, 2.3%, and 1.5% (P 90 mL/min/1.73 m2. Conclusions A simple concomitant volumetric analysis of all four cardiac chambers by CT pulmonary angiography demonstrated that differences in volume correlate with renal function even within the normal range spectrum. The difference was most evident in the left atrium. This finding may be the first clue to evolving cardiorenal syndrome and may serve as a target for early therapeutic interventions. Trial Registry ClinicalTrials.gov ; Clinical Trials registration number (Helsinki Committee): 0603-15-TLV; URL: www.clinicaltrials.gov . |
| Databáze: | OpenAIRE |
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